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  • Title: Beta-endorphinergic innervation of mu and delta receptor containing neurons in the dorsal raphe nucleus.
    Author: Wang QP, Guan JL, Nakai Y.
    Journal: Neuroreport; 1998 Sep 14; 9(13):3033-6. PubMed ID: 9804311.
    Abstract:
    A pre-embedding double immunostaining technique was used to determine the role of beta-endorphin in synapse, particularly in neurons with a postsynaptic membrane containing micro-1 or delta-1 opioid receptors. A small number of beta-endorphin immunoreactive axon terminals in the dorsal raphe nucleus was found to make direct synapses on micro-1 or delta-1 opioid receptor-immunoreactive dendrites, some of which showed immunostaining of their postsynaptic membranes, although with low frequencies. These results suggest that beta-endorphin can play a direct role through the micro-1 or delta-1 opioid receptors at synapses, but the main route would be through other opioid receptor at the synapse or even not through the synapse.
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