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  • Title: Phosphorylation and activation of p70 S6 kinase by manganese in PC12 cells.
    Author: Hirata Y, Adachi K, Kiuchi K.
    Journal: Neuroreport; 1998 Sep 14; 9(13):3037-40. PubMed ID: 9804312.
    Abstract:
    Previous study has shown that the treatment of PC12 cells with manganese, a MPTP-like neurotoxin, causes transcription-dependent apoptosis. This is a useful model system for the study of neuronal cell death. Manganese-induced apoptosis is accompanied by the induction of DNA fragmentation, expressions of c-Fos and c-Jun, and activation of the c-Jun N-terminal kinase U(JNK) pathway. Here, we report that manganese induces phosphorylation of p70 S6 kinase at Ser411 and Thr421/Ser424, and activates the enzyme. Thus, phosphorylation and activation of p70 S6 kinase are accompanied by transcription-dependent apoptosis, suggesting a role for p70 S6 kinase in this type of apoptosis.
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