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  • Title: The capillary filtration coefficient for evaluation of capillary fluid permeability in cat calf muscles.
    Author: Kongstad L, Grände PO.
    Journal: Acta Physiol Scand; 1998 Oct; 164(2):201-11. PubMed ID: 9805107.
    Abstract:
    Measuring the capillary filtration coefficient (CFC) from the transvascular fluid filtration following a fixed increase in transcapillary hydrostatic pressure is a common method to estimate capillary hydraulic permeability (conductivity) in an organ. Constant flow pump perfusion with an artificial perfusate and a maximally dilated vascular bed are often used in CFC studies to avoid influence on CFC of variations in vascular tone, blood flow and perfusion pressure. The present study evaluates if capillary hydraulic conductivity can be estimated by the CFC method, when analyzed on a denervated cat skeletal muscle with quite well-preserved local vascular control and perfused with autologous blood. CFC was estimated by increasing venous pressure and by decreasing tissue pressure, and both during autoperfusion and pressure controlled pump perfusion. A constant filtration rate was achieved 3-4 min after the transcapillary pressure elevation, giving a CFC around 0.0090 mL min-1 mmHg-1 100 g. The CFC did not change with arterial pressure or with reduced vascular tone using the tissue pressure method, but decreased slightly with increased arterial pressure and reduced vascular tone using the venous pressure method. CFC variations with arterial pressure were larger during pump perfusion in which myogenic reactivity is depressed, indicating that influence of myogenic tone on CFC is small. We conclude that CFC can be used to evaluate capillary hydraulic conductivity, and also when arterial pressure, vascular tone and blood flow are altered within reasonable physiological limits during the experiment, and the tissue pressure method and autoperfusion is to be preferred.
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