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  • Title: Infection of Hela cells with a virulent and an attenuated strain of pseudorabies virus studied by electron microscopy.
    Author: Golais F, Ciampor F.
    Journal: Acta Virol; 1976 Jun; 20(3):247-9. PubMed ID: 9806.
    Abstract:
    Hollow-core particles, forming crystals in nuclei, prevailed in HeLa cells infected with an attenuated strain of pseudorabies virus (PRV). After infection with a virulent PRV strain, the cells contained mainly fully infectious dense-core particles. These findings might explain the lower susceptibility of HeLa and some other human cells to infection with attenuated strains of PRV as compared to virulent strains.
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