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  • Title: CD8 expression allows T cell signaling by monomeric peptide-MHC complexes.
    Author: Delon J, Grégoire C, Malissen B, Darche S, Lemaître F, Kourilsky P, Abastado JP, Trautmann A.
    Journal: Immunity; 1998 Oct; 9(4):467-73. PubMed ID: 9806633.
    Abstract:
    Physiologically, TCR signaling is unlikely to result from the cross-linking of TCR-CD3 complexes, given the low density of specific peptide-MHC complexes on antigen-presenting cells. We therefore have tested directly an alternative model for antigen recognition. We show that monomers of soluble peptide-MHC trigger Ca2+ responses in CD8alphabeta+ T cells. This response is not observed in CD8- T cells and when either the CD8:MHC or CD8:Lck interactions are prevented. This demonstrates that an intact CD8 coreceptor is necessary for effective TCR signaling in response to monomeric peptide-MHC molecules. We propose that this heterodimerization of TCR and CD8 by peptide-MHC corresponds to the physiological event normally involved during antigen-specific signal transduction.
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