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  • Title: Comparative pathogenesis of haemorrhagic enteritis virus (HEV) infection in turkeys and chickens.
    Author: Rautenschlein S, Suresh M, Neumann U, Sharma JM.
    Journal: J Comp Pathol; 1998 Oct; 119(3):251-61. PubMed ID: 9807727.
    Abstract:
    The pathogenesis of haemorrhagic enteritis virus (HEV) infection in chickens 3-4 days post-infection was compared with that in turkeys. As expected, infected turkeys showed HEV-specific lesions that included enlargement and mottling of the spleen, as well as haemorrhagic enteritis. In infected chickens, only splenomegaly was observed. The number of HEV-infected cells in the spleen was significantly (P < 0.05) higher in the turkey than in the chicken. In both species, the immunohistochemical labelling of B-cell surface determinants was diminished and the splenic B-cell areas were undetectable after HEV infection. Infection with HEV resulted in an increase in nitric oxide production by macrophages in chickens but not in turkeys.
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