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  • Title: Peroxisomal and microsomal fatty acid oxidation in liver of rats after chronic ethanol consumption.
    Author: Orellana M, Rodrigo R, Valdés E.
    Journal: Gen Pharmacol; 1998 Nov; 31(5):817-20. PubMed ID: 9809485.
    Abstract:
    1. Microsomal P450 and peroxisomal fatty acid oxidation activities were studied in liver of rats after long-term ethanol consumption. 2. Ethanol increased the microsomal lauric acid omega-hydroxylation and the aminopyrine N-demethylation catalyzed by cytochrome P450. 3. Ethanol increased peroxisomal beta-oxidation of palmitoyl CoA and catalase activity in liver. 4. Both microsomal and peroxisomal activities behaved in a coordinate way in the liver of rats with long-term ethanol consumption. 5. These results would support a role of microsomal omega-hydroxylation and peroxisomal beta-oxidation of fatty acids in an extramitochondrial pathway of lipid oxidation in the liver.
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