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  • Title: Acute hemolytic crisis with fulminant hepatic failure as the first manifestation of Wilson's disease: a case report.
    Author: Lee JJ, Kim HJ, Chung IJ, Kook H, Byun JR, Kwon SY, Park MR, Choi KS, Hwang TJ, Ryang DW.
    Journal: J Korean Med Sci; 1998 Oct; 13(5):548-50. PubMed ID: 9811188.
    Abstract:
    We report a 27-year-old woman who developed Coombs' negative hemolytic anemia and fulminant hepatic failure as the initial manifestation of Wilson's disease. Unmeasurably low level of serum alkaline phosphatase provided a clue to the diagnosis of Wilson's disease. The diagnosis was established with the presence of Kayser-Fleischer ring, decreased serum ceruloplasmin level, and elevated urine and serum copper levels. In spite of repeated plasmapheresis, she died of multiorgan failure on the fifth hospital day.
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