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  • Title: Focal splenic defects.
    Author: Freeman MH, Tonkin AK.
    Journal: Radiology; 1976 Dec; 121(3 Pt. 1):689-92. PubMed ID: 981668.
    Abstract:
    Review of more than 2,000 liver-spleen scans revealed 18 cases of focal splenic defects. Three major categories are defined: lymphoma, infarctions, and metastatic tumor. Clinical presentation is important in determining the precise etiology, and a differential diagnosis is presented. It appears that: (a) reticulum cell carcinoma is as likely to cause defects as is Hodgkin's disease; (b) splenic infarction is related to pancreatic disease through the splenic vein; and (c) malignant melanoma is the most common secondary deposit as detected by scanning.
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