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  • Title: A sensitive method for the determination of amitriptyline and nortriptyline in human plasma.
    Author: Cooper TB, Allen D, Simpson GM.
    Journal: Psychopharmacol Commun; 1976; 2(2):105-16. PubMed ID: 981709.
    Abstract:
    A highly sensitive and reproducible GLC technique for the quantitation of amitriptyline and nortriptyline is described. The lower limit of detection is less than 1 ng/ml. 5 ng/ml samples (3 ml aliquots) can be accurately quantified (C of V less than 5%). Steady state data are reported together with data on amitriptyline and nortriptyline levels obtained in a volunteer who ingested a single oral dose (25 mg) of amitriptyline (Elavil).
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