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  • Title: Intrathecal clonidine for refractory detrusor hyperreflexia in spinal cord injured patients: a preliminary report.
    Author: Denys P, Chartier-Kastler E, Azouvi P, Remy-Neris O, Bussel B.
    Journal: J Urol; 1998 Dec; 160(6 Pt 1):2137-8. PubMed ID: 9817340.
    Abstract:
    PURPOSE: We assessed the urodynamic effect of various doses of intrathecal clonidine on refractory detrusor hyperreflexia in spinal cord injured patients. MATERIALS AND METHODS: Doses of 15, 30 or 45 microg. intrathecal clonidine or placebo were given to 5 chronic complete spinal cord injured patients with detrusor hyperreflexia. Two cystometries were performed before and 5, 30, 60, 90, 120 and 180 minutes after each injection. RESULTS: A statistically significant dose dependent decrease in detrusor hyperreflexia was observed in each patient without significant side effect. CONCLUSIONS: Intrathecal clonidine may represent a conservative reversible treatment for detrusor hyperreflexia via a subcutaneous programmable pump, like that used for baclofen, for spasticity. The long-term efficacy needs to be evaluated.
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