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  • Title: Role of DNA definite structural elements in interaction with repair enzyme uracil-DNA glycosylase.
    Author: Kubareva EA, Vasilenko NL, Vorobjeva OV, Volkov EM, Oretskaya TS, Korshunova GA, Nevinsky GA.
    Journal: Biochem Mol Biol Int; 1998 Oct; 46(3):597-606. PubMed ID: 9818099.
    Abstract:
    Interaction of different oligodeoxyribonucleotides (oligos), their analogs and oligonucleopeptide with uracil-DNA glycosylase (UDG) from human placenta was investigated. It is shown that there is no considerable contribution of heterocyclic bases of DNA to UDG-substrate binding but the UDG interaction with some DNA phosphate groups is necessary for enzyme-substrate recognition. However the phosphate group adjacent to single dU from the 3'-end in oligo is not involved into the electrostatic contact with UDG. It is found that UDG has the high affinity to its reaction product. An oligonucleotide containing a single 2'-deoxy-2'-aminouridine is a non-hydrolyzable substrate analog for UDG.
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