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  • Title: Complement diversity: a mechanism for generating immune diversity?
    Author: Sunyer JO, Zarkadis IK, Lambris JD.
    Journal: Immunol Today; 1998 Nov; 19(11):519-23. PubMed ID: 9818547.
    Abstract:
    Unlike mammalian species, several cold-blooded species have been shown to possess multiple forms of complement components. The multiple forms of C3 characterized in several fish species can bind with different specificities to various complement-activating surfaces. Here, Oriol Sunyer, Ioannis Zarkadis and John Lambris explore the possible advantages conferred by having multiple forms of individual complement proteins in a single organism.
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