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  • Title: Occupational asthma by Anisakis simplex.
    Author: Armentia A, Lombardero M, Callejo A, Martín Santos JM, Gil FJ, Vega J, Arranz ML, Martínez C.
    Journal: J Allergy Clin Immunol; 1998 Nov; 102(5):831-4. PubMed ID: 9819301.
    Abstract:
    BACKGROUND: No cases of occupational asthma caused by the inhalation of antigens from Anisakis simplex have been published. OBJECTIVE: The purpose of this study was to evaluate the possibility that A simplex can play a role in the asthma experienced by 2 workers when handling fish and fish flour. METHODS: Skin prick and bronchial challenge tests with A simplex were performed. We also carried out measurements of specific IgE to A simplex and immunoblotting. RESULTS: Both patients had strong positive skin test responses, challenge test responses, and specific IgE to A simplex. Immunoblotting showed that both patients also had IgE against several bands in the fish flour extract, suggesting contamination by Anisakis allergens. CONCLUSION: These 2 patients provide evidence for occupational asthma caused by A simplex, based on in vivo and in vitro tests for Anisakis-specific IgE.
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