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  • Title: Common variable immunodeficiency following Epstein-Barr virus infection.
    Author: Zuccaro G, Della Bella S, Polizzi B, Vanoli M, Scorza R.
    Journal: J Clin Lab Immunol; 1997; 49(1):41-5. PubMed ID: 9819672.
    Abstract:
    The authors present a case of a patient who developed recurrent bacterial upper respiratory and pulmonary infections and marked hypogammaglobulinemia with a gradual decrease of serum IgG, IgA and IgM some months after acute Epstein-Barr virus infection. Test for identification of lymphocyte subpopulation showed increased CD8+ T-cells with a surface phenotype (CD8+, CD57+, HLA-DR+) characteristic of virus-induced, activated cytotoxic cells. Viral investigations showed a positive anti-EBNA titer, an IgG titer anti-VCA of 1:40, a negative IgG titer anti-EA and human immunodeficiency virus negativity. The authors conclude that these clinical features are indicative of possible common variable immunodeficiency following Epstein-Barr virus infection.
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