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  • Title: Inhibition of fungal sphingolipid biosynthesis by rustmicin, galbonolide B and their new 21-hydroxy analogs.
    Author: Harris GH, Shafiee A, Cabello MA, Curotto JE, Genilloud O, Göklen KE, Kurtz MB, Rosenbach M, Salmon PM, Thornton RA, Zink DL, Mandala SM.
    Journal: J Antibiot (Tokyo); 1998 Sep; 51(9):837-44. PubMed ID: 9820234.
    Abstract:
    The mode of action of the known antifungal macrolides rustmicin (1) and galbonolide B (2) has been determined to be the inhibition of sphingolipid biosynthesis. A large scale fermentation and isolation process was developed for production of large quantities of rustmicin. New 21-hydroxy derivatives of both compounds were isolated from pilot scale fermentations and were also produced by biotransformation of rustmicin and galbonolide B.
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