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  • Title: Cytomegalovirus retinitis, human immunodeficiency virus antibody positivity and normal T helper cell numbers.
    Author: Thomson RM, Conrad D, Antoszewska H, Croxson MC, McCormack JG.
    Journal: J Infect; 1998 Sep; 37(2):186-8. PubMed ID: 9821096.
    Abstract:
    We describe a 46-year-old man in whom retinitis was diagnosed as his initial HIV and AIDS defining illness. A diagnosis of CMV infection was made based on the clinical appearance of the fundus and confirmed by DNA polymerase chain reaction (PCR) on his vitreous biopsy. His CD4+ T lymphocyte count at the time was 580 x 10(6)/l (16%) with a CD4:CD8 ration of 0.28. He had a splenectomy following trauma more than 20 years earlier. He responded very well to intravenous and oral ganciclovir and remains recurrence-free almost 2 years later. This case and others highlight two issues: (i) CMV retinitis in HIV positive is not confined to those with very low CD4+ T lymphocyte counts; (ii) previous splenectomy may have an impact on CD4+ cell numbers and function.
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