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  • Title: PPARgamma3 mRNA: a distinct PPARgamma mRNA subtype transcribed from an independent promoter.
    Author: Fajas L, Fruchart JC, Auwerx J.
    Journal: FEBS Lett; 1998 Oct 30; 438(1-2):55-60. PubMed ID: 9821958.
    Abstract:
    PPARgamma is a member of the peroxisome proliferator activated receptors (PPAR) subfamily of nuclear receptors. So far two PPARgamma isoforms, PPARgamma1 and PPARgamma2, were known in mammals. We describe the structure of a novel human PPARgamma subtype, PPARgamma3. The PPARgamma3 mRNA is transcribed from a novel promoter localized 5' of exon A2. PPARgamma3 mRNA expression was restricted to adipose tissue and large intestine. Similar to human PPARgamma1 and -2, PPARy3 is activated by thiazolidinediones and prostaglandin J derivatives and binds with high affinity to a PPRE.
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