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  • Title: Characterization of alkaline phosphatase genes expressed in seminoma by cDNA cloning.
    Author: Shigenari A, Ando A, Baba T, Yamamoto T, Katsuoka Y, Inoko H.
    Journal: Cancer Res; 1998 Nov 15; 58(22):5079-82. PubMed ID: 9823315.
    Abstract:
    Two members of a placental alkaline phosphatase (PLAP) family, PLAP and PLAP-like or germ cell alkaline phosphatase, are aberrantly expressed in tumors of ecotropic origin. To characterize alkaline phosphatase induced in seminoma, alkaline phosphatase cDNA clones were isolated from a cDNA library constructed from seminoma cells and characterized by nucleotide sequence determination. Thus, isolated cDNA clones were classified into two types, germ cell alkaline phosphatase (PLAP-like) and liver/bone/kidney-type alkaline phosphatase (L/B/K AP). These results suggest that other than the PLAP family members, the expression of L/B/K AP is enhanced in seminoma and can serve as a tumor marker in seminoma.
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