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  • Title: Steroid C-21-hydroxylation by dog adrenal microsomes.
    Author: Horn H, Maschler I.
    Journal: Steroids; 1976 Sep; 28(3):405-9. PubMed ID: 982497.
    Abstract:
    1,2-3H121-Deoxycortisol (1) 1,2-3H21-deoxycortisone and 1,2-3H-17OH-progesterone were incubated separately with dog adrenal microsomes. With substrates concentrations of 30 and 150 nmoles all the substrates were hydroxylated at C-21 to a similar extent. This result suggests that 21-deoxycortisol could be an intermediate in the biosynthesis of cortisol provided it is avilable in vivo.
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