These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Capsular polysaccharide of Streptococcus pneumoniae type 19F: synthesis of the repeating unit.
    Author: Bousquet E, Khitri M, Lay L, Nicotra F, Panza L, Russo G.
    Journal: Carbohydr Res; 1998 Oct; 311(4):171-81. PubMed ID: 9825520.
    Abstract:
    A new and more versatile synthesis of beta-D-ManpNAc-(1-->4)-alpha-D-Glcp-(1-->2)-alpha-L-Rhap, the trisaccharide repeating unit of the Streptococcus pneumoniae type 19F capsular polysaccharide, is described. The present approach allows a simple access to different fragments containing the trisaccharide and the conjugation of the product(s) to a protein through the selective manipulation of the anomeric position at the reducing end and of the HO-4 function at the nonreducing end. The synthetic scheme shows an efficient application of the sulfoxide method for the stereoselective and high yielding formation of the glycosidic linkages.
    [Abstract] [Full Text] [Related] [New Search]