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  • Title: Vulvar squamous carcinoma: prognostic role of DNA content.
    Author: Mariani L, Conti L, Atlante G, Sciarretta F, Pozzi M, Vercillo M, Francavilla V, De Franceschi L, Rossi S, Sindico R, Atlante M, Gandolfo GM.
    Journal: Gynecol Oncol; 1998 Nov; 71(2):159-64. PubMed ID: 9826454.
    Abstract:
    DNA nuclear content was evaluated on 46 paraffin-embedded blocks of vulvar cancer by means of flow cytometry. Fifteen of 44 evaluable samples (34%) were found to have an aneuploid DNA pattern. Aneuplody showed a statistically significant relationship with tumor grading (P = 0.0004) and defined a subset of patients who have pathological characteristics of high risk, such as advanced stage of disease, deepest stromal invasion, or positive inguinal nodes. However, when a multivariate regression model was used, ploidy status did not have any prognostic role, while FIGO staging system was confirmed to be the strongest independent prognostic factor (P = 0.009). The integration of a panel of cell kinetic parameters with traditional features is worth investigating on a larger population.
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