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  • Title: Human prothrombin fragment 1 and 2 inhibit bFGF-induced BCE cell growth.
    Author: Rhim TY, Park CS, Kim E, Kim SS.
    Journal: Biochem Biophys Res Commun; 1998 Nov 18; 252(2):513-6. PubMed ID: 9826562.
    Abstract:
    Previously, we reported that the rabbit prothrombin fragment 2 (kringle 2 domain) has an anti-endothelial cell proliferative effect (Lee et al., J. Biol. Chem., in press). In this report, we show that not only rabbit prothrombin fragment 2 but also human prothrombin fragment 1 and 2 have an inhibitory effect on bFGF-stimulated BCE cell growth. Human prothrombin fragment 1 and 2 obtained as proteolytic fragments of human prothrombin display potent inhibitory effects on bovine capillary endothelial cells with a half-maximal concentration (ED50) of approximately 100 nM and 120 nM, respectively. As rabbit prothrombin fragment 2, the human prothrombin fragment 1 and 2 also inhibit angiogenesis in the chorioallantoic membrane (CAM) of chick embryos.
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