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  • Title: A novel antiprotozoal aminosteroid from Saracha punctata.
    Author: Moretti C, Sauvain M, Lavaud C, Massiot G, Bravo J, Muñoz V.
    Journal: J Nat Prod; 1998 Nov; 61(11):1390-3. PubMed ID: 9834160.
    Abstract:
    A new aminosteroid, 3beta-amino-22,26-epiminocholest-5-ene named sarachine (1), and two known flavonoids, eriodictyol (2) and 7-O-beta-D-glucopyranosyl-eriodictyol (3), were isolated from the leaves of Saracha punctata. The alkaloid was found to inhibit the growth of Leishmania braziliensis promastigotes (100% at 25 microM) and of Trypanosoma cruzi epimastigotes in culture (50% at 25 microM) and showed a strong in vitro antiplasmodial activity with an IC50 of 25 nM.
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