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  • Title: Protein and lipid sorting from the trans-Golgi network to the plasma membrane in polarized cells.
    Author: Ikonen E, Simons K.
    Journal: Semin Cell Dev Biol; 1998 Oct; 9(5):503-9. PubMed ID: 9835637.
    Abstract:
    The targeting of proteins and lipids to the cell surface domains of polarized cells is not a simple bulk flow process but requires sorting into distinct apical and basolateral pathways from the trans-Golgi network. Here, we describe the sorting determinants in the cargo molecules, the cellular sorting machineries responsible for the hierarchical read-out of the signals, and the mechanisms of cargo delivery. Furthermore, we discuss the implications of these findings for protein-lipid interactions in other cellular machineries.
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