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  • Title: Determination of celiprolol and oxprenolol in human plasma by high-performance liquid chromatography and the analytical error function.
    Author: Braza AJ, Modamio P, Mariño EL.
    Journal: J Chromatogr B Biomed Sci Appl; 1998 Nov 06; 718(2):267-72. PubMed ID: 9840437.
    Abstract:
    Two reversed-phase HPLC methods with UV detection to quantify celiprolol and oxprenolol in human plasma are described. The analytical methods for the determination of both drugs used the same reversed-phase HPLC column, mobile phase and extraction procedure. Linearity was obtained in the ranges 15.63-1000 and 25-800 ng/ml for celiprolol and oxprenolol, respectively. Intra-day and inter-day variation was lower than 14%. After validation of the methods, analytical error functions were established as S.D. (ng/ml)=3.096+0.041C for celiprolol and S.D. (ng/ml)=8.906+8.075x10(-8)C3 for oxprenolol.
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