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  • Title: Reversal of the anaesthetic action of sodium gamma-hydroxybutyrate.
    Author: Henderson RS, Holmes CM.
    Journal: Anaesth Intensive Care; 1976 Nov; 4(4):351-4. PubMed ID: 984396.
    Abstract:
    Physostigmine was administered intravenously to 25 patients, anaesthetised with sodium gamma-hydroxybutyrate (GHB), and their emergence from anesthesia was studied. Physostigmine (2 mg) brought about rapid, safe, reliable and sustained awakening after a "latent period" varying from 2-10 minutes (mean 6-2 minutes+/-S.D. 2-2) in 24 patients. In the one patient not awake at 10 minutes, a second dose of physostigmine produced awakening in an additional 8 minutes. No serious side effects were attributable to the physostigmine. This finding may warrant a reconsideration of the place of GHB in anaesthetic practice.
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