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  • Title: In vitro effect of angiotensin II on GABA release in rat hippocampus.
    Author: Hadjiivanova CH, Georgiev V.
    Journal: Neuropeptides; 1998 Oct; 32(5):431-4. PubMed ID: 9845003.
    Abstract:
    In rat hippocampal slices [3H]GABA release evoked by 25 mM KCI consisted of Ca2+-dependent and Ca2+-independent fractions. Angiotensin II (AngII) at a concentration of 1 microM inhibited K+-stimulated [3H]GABA release. The effect of AngII (20% inhibition) on [3H]GABA release was decreased by the addition of 0.01 mM nipecotic acid to the superfusion medium. AngII also decreased the Ca2+-independent carrier-mediated [3H]GABA release (25% inhibition at a concentration of 1 microM). Different mechanisms of the neuromodulatory action of AngII on GABA release are discussed.
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