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  • Title: [Relationship between genotype of angiotensin converting enzyme gene and left ventricular hypertrophy in Chinese hypertensives].
    Author: Shen D, Ha D, Bai C.
    Journal: Zhonghua Yi Xue Yi Chuan Xue Za Zhi; 1998 Dec 10; 15(6):364-6. PubMed ID: 9845769.
    Abstract:
    OBJECTIVE: To search into the relationship between genotype of angiotensin-converting enzyme (ACE) gene and left ventricular hypertrophy(LVH) in Chinese hypertensives. METHODS: ACE genotyping with polymerase chain reaction (PCR) was performed in 33 unrelated hypertensives with LVH, 55 hypertensives without cardio-cerebrovascular diseases and 62 healthy controls. RESULTS: The frequencies of DD genotype (0.394) and deletion allele (0.606) among hypertensives with LVH were significantly higher than those (0.129 and 0.387) among controls and those (0.128 and 0.400) among hypertensives without cardio-cerebrovascular diseases. CONCLUSION: A deletion polymorphism of ACE gene probably increases the risk for left ventricular hypertrophy in Chinese hypertensives.
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