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  • Title: [Resuming of thermoregulation in rats during deep hypothermia with EDTA without rewarming the body].
    Author: Arokina NK.
    Journal: Ross Fiziol Zh Im I M Sechenova; 1998 Aug; 84(8):806-13. PubMed ID: 9845899.
    Abstract:
    Administration of the EDTA, a substance binding calcium ions, helped to resume thermoregulation functions after their "cold paralysis" at the rectal temperature 17.1 +/- 0.2 degrees C and the brain temperature 19.2 +/- 0.2 degrees C, without warming up the animal. Enhancement of the muscle electrical activity following the EDTA administration was due both to increase in the number of bursts of shivering and to enhancement of their intensity. The findings suggest that, in hypothermia, improvement of conditions of the calcium ion transport from the cell cytosole into interstitial space helps to restoration of the cold muscle shivering as an important function of the thermoregulation.
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