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  • Title: 14q11 abnormality and trisomy 8q are not common in Japanese T-cell prolymphocytic leukemia.
    Author: Kojima K, Kobayashi H, Imoto S, Nakagawa T, Matsui T, Kawachi Y, Oda K, Yano T, Kobayashi H, Noguchi M, Hara M, Oshimi K.
    Journal: Int J Hematol; 1998 Oct; 68(3):291-6. PubMed ID: 9846013.
    Abstract:
    We studied ten cases of Japanese T-cell prolymphocytic leukemia (T-PLL) collected over the last 9 years. Median age was 61 years with a male predominance (M:F, 8:2). The main disease features were splenomegaly, lymphadenopathy, hepatomegaly, skin lesions and serous effusions. The clinical course was progressive with a median survival of 10 months. Immunophenotyping showed that the prolymphocytes had a post-thymic phenotype (TdT-, CD1a-, CD2+, CD3+, CD5+, CD7+) with a predominant CD4+ immunophenotype. Cytogenetic analysis showed no consistent abnormalities. 14q abnormality and trisomy 8q, which are frequently seen in T-PLL of Western countries, were found in only two and zero cases, respectively. We conclude that the clinical and biological characteristics of T-PLL in Japan are almost the same as those in Western countries. However, the cytogenetic findings of T-PLL in Japan might be different.
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