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  • Title: Laboratory evaluation of BL-S786, a cephalosporin with broad-spectrum antibacterial activity.
    Author: Leitner F, Misiek M, Pursiano TA, Buck RE, Chisholm DR, DeRegis RG, Tsai YH, Price KE.
    Journal: Antimicrob Agents Chemother; 1976 Sep; 10(3):426-35. PubMed ID: 984784.
    Abstract:
    Biological and physicochemical properties of BL-S786 were compared with those of cephalothin, cephaloridine, and cefazolin. With few exceptions, BL-S786 was more active than the reference compounds against major gram-negative pathogenic species and its antibacterial spectrum was broader than that of cephalosporins currently available for clinical use. Although BL-S786 was generally less active than the control cephalosporins against gram-positive pathogens, it inhibited their growth at concentrations that should readily be achieved in humans after standard parenteral dosage. Streptococcus faecalis, a species relatively unsusceptible to cephalosporins in general, was an exception. BL-S786 was an effective bactericidal agent for strains of various gram-negative organisms. After intramuscular administration to mice, BL-S786 achieved high concentrations in blood, and its biological half-life was longer than that of the other three cephalosporins.
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