These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Therapeutic effects of ribavirin given by the intraperitoneal or aerosol route against influenza virus infections in mice.
    Author: Stephen EL, Dominik JW, Moe JB, Walker JS.
    Journal: Antimicrob Agents Chemother; 1976 Sep; 10(3):549-54. PubMed ID: 984796.
    Abstract:
    Ribavirin (1-beta-d-ribofuranosyl-1,2,4-triazole-3-carboxamide) is an effective antiviral agent against type A influenza infection of mice. Therapy was most effective when administered as a small-particle aerosol early in the infection. Treatment was also effective by either the intraperitoneal or aerosol route in mice with histological evidence of pneumonia. Ribavirin increased the percent survival, lowered lung virus titers, and decreased the development of lung pathology when therapy was initiated at 6 h as a small-particle aerosol. There was no evidence of pulmonary toxicity or immunosuppressive effects.
    [Abstract] [Full Text] [Related] [New Search]