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  • Title: [The sensitivity of catalytic subunit isoforms of Na+,K+-ATPase of rat brain to peroxide membrane modification].
    Author: Kaplia AA.
    Journal: Ukr Biokhim Zh (1978); 1998; 70(4):118-22. PubMed ID: 9848212.
    Abstract:
    The comparative study of the sensitivity of Na+, K(+)-ATPase isozymes from cerebral cortex to ascorbate-dependent membrane peroxidation was conducted. With highly inactivated Na+, K(+)-ATPase the degree of inactivation of the SH-dependent ouabain-sensitive forms alpha+ (alpha 2 and alpha 3) is higher than glycoside-resistant isoform alpha 1. The process is accompanied by simultaneous lipid peroxidation and decrease of SH-groups amount in enzyme preparations. The combined nature of the oxidative Na+, K(+)-ATPase inactivation, accompanied by the direct oxidation of enzyme SH-groups and modification of lipid environment is supposed.
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