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  • Title: [Intra-arterial application of the ACE inhibitor ramipril using a microperforated catheter for the prevention of neointimal proliferation after angioplasty in an animal model].
    Author: Kalinowski M, Tepe G, Schieber A, Bruck B, Claussen CD, Duda SH.
    Journal: Rofo; 1998 Nov; 169(5):532-6. PubMed ID: 9849606.
    Abstract:
    PURPOSE: To evaluate the safety and benefit of a high-dose local drug administration via a microporous balloon catheter to prevent neointimal formation after balloon angioplasty. MATERIALS AND METHODS: In New Zealand white rabbits (n = 29) neointima formation was induced by balloon denudation. Additionally, the animals were fed a 0.5% cholesterol diet for 6 weeks. Directly after the denudation, local application of 1.8 mg ramipril (n = 7) or saline (n = 7) via a microporous balloon catheter was performed. Other animals (n = 7) were treated with a systemic ramipril administration. One control group were exclusively fed with a cholesterol diet (n = 8). 6 weeks after intervention the animals were sacrificed and morphometry of the vessels was performed. RESULTS: Local administration of ramipril resulted in a non-significant reduction of 17%. The local administration mode was combined with a significant increase in neointima formation. Systemic ramipril administration resulted in a 66% reduction of plaque area. CONCLUSIONS: The benefit of the local ramipril administration was diminished by the inherent vessel trauma. Systemic ramipril administration resulted in a significant reduction of neointimal proliferation in New Zealand white rabbits.
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