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  • Title: [The action of tiadenol on compensatory hypertrophy of the liver in the rat].
    Author: Rozé C, Vaille C, Souchard M, De la Tour J, Debray C.
    Journal: Arch Int Pharmacodyn Ther; 1976 Jul; 222(1):166-76. PubMed ID: 984967.
    Abstract:
    The regenerating rat liver after partial hepatectomy was used as a model to study the effects of an hypolipidaemic drugs, tiadenol (bis hydroxyethylthio 1--10 decane). Seven days after partial hepatectomy, liver weight, DNA, RNA, total protein and cytochrome P-450 were increased in tiadenol treated rats, relative to hepatectomized controls. Tiadenol displaying similar effects on the intact liver, it is concluded that this hypolipidaemic drug maintains its hepatomegalic action on the regenerating rat liver.
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