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  • Title: Utility of anti-Hu antibodies in the diagnosis of paraneoplastic sensory neuropathy.
    Author: Molinuevo JL, Graus F, Serrano C, Reñe R, Guerrero A, Illa I.
    Journal: Ann Neurol; 1998 Dec; 44(6):976-80. PubMed ID: 9851446.
    Abstract:
    Anti-Hu antibodies (Hu-Abs) were positive in 40 patients with paraneoplastic sensory neuropathy (PSN) and in 1 patient with idiopathic sensory neuropathy in a series of 126 patients who presented with clinical features suggestive of PSN. The specificity of Hu-Abs was 99% and the sensitivity was 82%. Nine (18%) PSN patients were Hu-Ab-negative, and their sera did not harbor other specific anti-neuronal or anti-ganglioside antibodies. Small cell lung carcinoma (SCLC) was the leading neoplasm in the Hu-Ab-positive (79%) and Hu-Ab-negative (44%) groups. This study confirms the value of Hu-Abs for the diagnosis of PSN and SCLC and also emphasizes that in patients with possible PSN, the absence of Hu-Abs does not exclude cancer, particularly in those patients with risk factors for SCLC.
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