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Title: The effect of acidosis in hypokalemic periodic paralysis. Author: Jarrell MA, Greer M, Maren TH. Journal: Arch Neurol; 1976 Nov; 33(11):791-3. PubMed ID: 985160. Abstract: Metabolic acidosis was produced in two patients with hypokalemic periodic paralysis by the administration of ammonium chloride over a period of three days. The challenging test of glucose and insulin produced a substantially smaller reduction of both serum potassium concentration and muscle strength than when the patients were tested in normal acid-base balance. The findings agree with earlier work on acetazolamide, suggesting that metabolic acidosis provides protection against episodes of muscle weakness in periodic paralysis.[Abstract] [Full Text] [Related] [New Search]