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  • Title: GB virus C/hepatitis G virus and intravenous immunoglobulins.
    Author: Nübling C, Gröner A, Löwer J.
    Journal: Vox Sang; 1998; 75(3):189-92. PubMed ID: 9852405.
    Abstract:
    BACKGROUND AND OBJECTIVES: Different intravenous immunoglobulins (IVIGs) were found to be GB virus C/hepatitis G virus polymerase chain reaction (GBV-C/HGV-PCR)-positive. The potential transmission of this virus to recipients by a PCR-positive IVIG batch was investigated. MATERIALS AND METHODS: Polyclonal IVIGs of different manufacturers and with different virus inactivation procedures were analyzed by GBV-C/HGV-PCR and anti-E2-ELISA. Follow-up sera of 13 participants of a clinical trial performed with a GBV-C/HGV-PCR-positive batch were retrospectively investigated for GBV-C/HGV seroconversion (specific antibodies, viral RNA). RESULTS: Four out of ten IVIGs analysed by GBV-C/HGV-PCR were - at least for some batches - virus genome-positive. Virus inactivation by solvent/detergent treatment resulted in GBV-C/HGV-PCR-negative products. GBV-C/HGV-specific antibodies were detectable in all IVIGs analyzed. There was no transmission of GBV-C/HGV observed when recipients of a large amount of a GBV-C/HGV-PCR-positive batch were analyzed by an antibody test and specific PCR. CONCLUSIONS: Despite PCR positivity of an IVIG preparation no transmission of GBV-C/HGV to recipients was observed. Possible explanations are a sufficient virus inactivation procedure and/or presence of specific antibodies in the final products.
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