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  • Title: Adenovirus E4orf6 oncoprotein modulates the function of the p53-related protein, p73.
    Author: Higashino F, Pipas JM, Shenk T.
    Journal: Proc Natl Acad Sci U S A; 1998 Dec 22; 95(26):15683-7. PubMed ID: 9861030.
    Abstract:
    Recently, several proteins have been identified that are related in their sequence to the p53 tumor-suppressor protein. One of these proteins, which is termed p73, exhibits sequence homology to the p53 transcriptional activation, DNA binding, and oligomerization domains. The adenovirus E1B 55-kDa protein, the adenovirus E4orf6 protein, and SV40 T antigen each can bind to p53 and inhibit p53 function. Here we demonstrate that the adenovirus E4orf6 protein, but not the E1B 55-kDa protein or T antigen, interacts with p73. The E4orf6 protein inhibits p73-mediated transcriptional activation and cell killing in a manner similar to its effect on p53. Thus, only a subset of viral oncoproteins that antagonize p53 function also interacts with the related p73 protein.
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