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  • Title: Expression of an oncogenic mutant G alpha i2 activates Ras in Rat-1 fibroblast cells.
    Author: Edamatsu H, Kaziro Y, Itoh H.
    Journal: FEBS Lett; 1998 Nov 27; 440(1-2):231-4. PubMed ID: 9862461.
    Abstract:
    It has been reported that expression of the active mutant of heterotrimeric GTP-binding protein alpha subunit G alpha i2 transforms Rat-1 cells. However, the G alpha i2-mediated mitogenic signaling pathways remain to be elucidated. Here, we demonstrate that inducible expression of the active mutant of G alpha i2 (G alpha i2(Q205L)) activates Ras and c-Jun N-terminal kinase (JNK) in addition to extracellular signal-regulated kinase (ERK) in Rat-1 cells. Our findings suggest that Ras may play a critical role in the G alpha i2-induced transformation and G alpha i2 can transduce signals from the Gi-coupled receptor to JNK and ERK in certain types of mammalian cells.
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