These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Inhibitory effects of m-nifedipine on angiotensin II stimulated proliferation and protein synthesis in cultured rabbit aortic smooth muscle cells].
    Author: Gu HB, Tang YH, Xu Y.
    Journal: Yao Xue Xue Bao; 1996; 31(10):732-6. PubMed ID: 9863239.
    Abstract:
    By using rabbit aortic smooth muscle cells (VSMC) in culture as a model, the effects of m-nifedipine (m-Nif) on the growth of VSMC were observed. The results showed that m-Nif inhibited [3H]-thymidine and [3H]-leucine incorporation into DNA and protein, decreased cell number in a concentration-dependent manner in angiotensin II (ANG II) induced VSMC. At the concentration of 2 mumol.L-1, m-Nif was found to reduce the ANG II (100 nmol.L-1) stimulated [3H]-thymidine, [3H]-leucine incorporation and cell number by 46%, 58% and 53%, respectively. Our results suggest that m-Nif can inhibit ANG II stimulated proliferation and protein synthesis in cultured rabbit aortic VSMC.
    [Abstract] [Full Text] [Related] [New Search]