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  • Title: [Paroxysmal nocturnal hemoglobinuria in pregnancy].
    Author: Lange JG, Griever GE, Brand A, van Roosmalen J.
    Journal: Ned Tijdschr Geneeskd; 1998 Oct 17; 142(42):2308-11. PubMed ID: 9864527.
    Abstract:
    The combination of paroxysmal nocturnal haemoglobinuria (PNH) and pregnancy occurred in three women aged 29, 31 and 35 years. One patient had a spontaneous abortion twice after which she committed suicide. In the other two the pregnancy and parturition--assisted--were without complications. However, one woman developed post-partum abdominal crises. The children were born at term and healthy. PNH is a rare form of haemolytic anemia. Pregnancy causes lethal complications in 6% of the cases of PNH, while 30% of the pregnancies end in spontaneous abortion or stillbirth. Accurate monitoring of pregnancy and the puerperium is essential.
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