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  • Title: Twelve-month comparative multicenter study of the TCu 380A and ML 250 intrauterine devices in Bangkok, Thailand.
    Author: Reinprayoon D, Gilmore C, Farr G, Amatya R.
    Journal: Contraception; 1998 Oct; 58(4):201-6. PubMed ID: 9865999.
    Abstract:
    The long-term effectiveness of the copper-bearing intrauterine device (IUD) has been documented. This paper reports 12-month results from a multiyear comparative study of the Copper T (TCu) 380A and Multiload (ML) 250 IUD in Bangkok, Thailand, among 1396 women. Continuation of the assigned IUD was relatively high after 12 months of use, with continuation rates of 90.17 and 87.54 per 100 women, respectively. Whereas the accidental pregnancy rate was higher for the ML 250 IUD than for the TCu 380A IUD (1.0 and 0.2 per 100 women, respectively), this difference was not considered statistically significant (p < 0.69). The rate of IUD expulsion was significantly higher among women using the ML 250 IUD than for women using the TCu 380A IUD (4.61 and 2.40 per 100 women, respectively, p = 0.05). The performance of the Copper T 380A and Multiload 250 IUDs over a 4-year period were compared in a prospective study of 1396 women from Bangkok, Thailand, who were randomly assigned to be fitted with 1 of the 2 devices. This paper presents the findings from the first 12 months (1995-96) of the study. At insertion, 8-10% of women in both groups reported mild pelvic pain. After 12 months of use, the continuation rate was 90.2% for the Copper T 380A and 87.5% for the Multiload 250 device. Menstrual problems were the most common complaint during the follow-up period; such disturbances--primarily spotting and dysmenorrhea--were reported by 59.1% of Copper T 380A users and 44.4% of women in the Multiload 250 group. The accidental pregnancy rate after 12 months was higher, but nonsignificantly, among Multiload 250 users (1.0/100 women) than Copper T 380A acceptors (0.2/100 women). The IUD expulsion rate was significantly higher among Multiload 250 acceptors (4.61%) than users of the Copper T 380A (2.4%). The higher efficacy, lower risk of expulsion, and longer life span (10 years) of the Copper T 380A compared to the Multiload 250 IUD suggest this is an ideal method for women who desire long-term protection against pregnancy but do not wish to be sterilized.
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