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  • Title: [The structural organization of the aortic endothelium in hypercholesterolemia and the effect of L-arginine].
    Author: Tkachenko MM, Stechenko LO, Sahach VF.
    Journal: Fiziol Zh (1994); 1998; 44(5-6):59-64. PubMed ID: 9866026.
    Abstract:
    Electron microscopic investigation of the rabbit [correction of rat] thoracic aorta revealed endothelium to be most vulnerable to the damage in experimental hypercholesterolemia. Administration of precursor of nitric oxide L-arginine against the background of hypercholesterolemia resulted in activation of functional activity of the endothelium of aorta. This notion is supported by an increase of the quantity of protein-synthesizing structures (ribosomes, polysomes, canaliculi of endoplasmic network), secretory granules vs rabbits on atherogenic diet. At stimulation of NO-synthase activity of endothelium the dilatory reactions of aortal strips to acetylcholine are improved.
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