These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Interactions between carotid sinus mechanoreceptor and chemoreceptor reflex loops.
    Author: Attinger FM, Attinger EO, Cooperson D, Gottschalk W.
    Journal: Pflugers Arch; 1976 Jun 22; 363(3):255-61. PubMed ID: 986611.
    Abstract:
    Our experiments were designed to evaluate the combined influence of the mechanoreceptor and chemoreceptor control loops on the cardiovascular and respiratory systems. Both carotid sinus areas were isolated by a complete blind sac preparation in chloralose anesthetized dogs in which a flow probe had been implanted previously on the ascending aorta. The following variables were continuously monitored: central aortic pressure, heart rate, cardiac output, vascular resistance of a hind limb, tidal volume, respiratory rate, and oxygen consumption. While one sinus was submitted to step changes of pressure, the opposite sinus was kept at constant mean pressure. In addition, one sinus was perfused with either oxygenated of deoxygenated blood at constant flow rate. These studies show a definite interaction between the control loops initiated by the carotid sinus mechanoreceptors and those initiated by the chemoreceptors. The influence of the chemoreceptors is most marked in the peripheral beds, where it shifts the whole response curve of the mechanoreceptor control loop upward. This response accounts for most of the upward shift of the pressure response curve. On the other hand, the mechanoreceptor loop affects the ventilation, but this effect is range dependent, being most marked for the low pressure perfusion of the carotid sinus.
    [Abstract] [Full Text] [Related] [New Search]