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  • Title: [Studies of childhood non-Hodgkin's lymphoma--treatment results with the CCLSG NHL 960 protocol. Children's Cancer and Leukemia Study Group (CCLSG)].
    Author: Tsurusawa M, Katano N, Hirota T, Ito M, Yanase T, Asami K, Koizumi S, Nakayama M, Miyawaki T, Suzumiya J, Nishikawa K, Mugisima H, Horikoshi Y, Hatae Y, Iwai A, Anami K, Kikuchi M, Osima K, Kaneko Y, Kataoka S, Tanaka A, Chin M, Taga T, Watanabe A, Fujimoto T.
    Journal: Rinsho Ketsueki; 1998 Nov; 39(11):1092-8. PubMed ID: 9866420.
    Abstract:
    We report here on the preliminary treatment findings of a CCLSG NHL 960 study that was initiated in March 1996. In this study, 37 patients with non-Hodgkin's lymphoma were assigned to 4 different treatment groups according to disease stage and histology: (1) localized disease; (2) advanced disease, lymphoblastic type; (3) advanced disease, large cell type; and (4) advanced disease, Burkitt type. The first three groups received the modified protocols of the NHL 890 study. Groups 1 and 3 received COPADM induction therapy (CPM, VCR, PRD, ADR, and MTX). After achieving remission, Group 1 received only maintenance therapy consisting of alternate administration of 7 drugs, while Group 3 received additional intensification therapy with combination chemotherapy consisting of MTX and Ara-C, followed by a maintenance phase involving the administration of 9 drugs. Group 2 received COPADL induction therapy (CPM, VCR, PRD, ADR, and LASP) and consolidation/intensification therapies followed by a maintenance phase. Group 4 received short-term intensive COPADM polychemotherapy. Twelve patients with localized with localized disease (stage I-II) and 25 patients with advanced disease (stage III-IV) were enrolled in this study. Except for 2 patients in the advanced disease stages who died earlier in the course of the study, all patients remained in remission.
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