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  • Title: [Drug-induced agranulocytosis: clinical study of 19 cases].
    Author: Márquez JA, Pardo C, Amutio E, Cortés C, Piñán MA, Alvarez C.
    Journal: Sangre (Barc); 1998 Oct; 43(5):436-8. PubMed ID: 9868339.
    Abstract:
    Agranulocytosis is one of the most serious side effects to drugs. From January 1991 to June 1996 were diagnosed 19 cases of agranulocytosis associated with drugs at our hospital (incidence rate: 9.4 over million hab. per year). The average age was 62 and 11 cases were women. The drugs most commonly involved were metamizol and ticlopidine. In 15 of the patients fever blew up and 16 presented some infectious location. In 9 of the cases some positive microbiological culture was obtained, gram-negative bacilli being the commonest. G-CSF was used in 13 of the patients, observing a quicker haematological recovery (5.7 days vs 9.1, p = 0.07), though without any difference in mortality, which was of 0%. All this leads to the following conclusions: a high incidence of agranulocytosis in our environment and the important role of metamizol and ticlopidine in its origin.
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