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  • Title: Novel HIV-protease inhibitors containing beta-hydroxyether and -thioether dipeptide isostere surrogates: modification of the P3 ligand.
    Author: Patel NM, Bennett F, Girijavallabhan VM, Dasmahapatra B, Butkiewicz N, Hart A.
    Journal: Bioorg Med Chem Lett; 1998 Apr 21; 8(8):931-4. PubMed ID: 9871514.
    Abstract:
    Studies involving modifications to the P3 position of previously described HIV-protease inhibitors containing beta-hydroxyether and thioether dipeptide isostere replacements led to the discovery of pseudopeptides 8o and 8p with improved antiviral activities.
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