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  • Title: Synthesis of C2 alkynylated purines, a new family of potent inhibitors of cyclin-dependent kinases.
    Author: Legraverend M, Ludwig O, Bisagni E, Leclerc S, Meijer L.
    Journal: Bioorg Med Chem Lett; 1998 Apr 07; 8(7):793-8. PubMed ID: 9871543.
    Abstract:
    The synthesis of a new family of inhibitors of the cell cycle regulating cyclin-dependent kinases (CDK's) is reported. These compounds, related to the purines olomoucine and roscovitine, are characterised by the presence of alkynylated side chains at C2. They inhibit CDK's with IC50's in the 200 nM range.
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